What is the impact of education on Huntington's disease?
Identifieur interne : 001275 ( Main/Exploration ); précédent : 001274; suivant : 001276What is the impact of education on Huntington's disease?
Auteurs : Jose Luis L Pez-Send N [Espagne] ; Ana Royuela [Espagne] ; Patricia Trigo [Espagne] ; Michael Orth [Allemagne] ; Herwig Lange [Allemagne] ; Ralf Reilmann [Allemagne] ; Jennifer Keylock [Royaume-Uni] ; Hugh Rickards [Royaume-Uni] ; Silvia Piacentini [Italie] ; Ferdinando Squitieri [Italie] ; Bernhard Landwehrmeyer [Allemagne] ; Marie-Noelle Witjes-Ane [Pays-Bas] ; Caroline. K. Jurgens [Pays-Bas] ; Raymund. A. C. Roos [Pays-Bas] ; Victor Abraira [Espagne] ; Justo. G. De Yébenes [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
English descriptors
- KwdEn :
- Adult, Age of Onset, Cognition Disorders (etiology), Educational Status, Family Health, Female, Humans, Huntington Disease (complications), Huntington Disease (genetics), Huntington Disease (psychology), Huntington's disease, Male, Mental Disorders (etiology), Middle Aged, Phenotype, Regression Analysis, Severity of Illness Index, Trinucleotide Repeat Expansion (genetics), UHDRS scores, age at onset, education, neuroprotection.
- MESH :
- complications : Huntington Disease.
- etiology : Cognition Disorders, Mental Disorders.
- genetics : Huntington Disease, Trinucleotide Repeat Expansion.
- psychology : Huntington Disease.
- Adult, Age of Onset, Educational Status, Family Health, Female, Humans, Male, Middle Aged, Phenotype, Regression Analysis, Severity of Illness Index.
Abstract
Huntington's disease (HD) is a neurodegenerative disease caused by a cytosine adenosine guanine (CAG) expansion in the huntingtin gene. The length of the triplet repeat is the most important factor in determining age of onset and the severity of the disease, but substantial variability of these parameters is attributed to other factors. To investigate the relationship between the years of education and the age at onset and the severity of the phenotype in patients with HD, we applied multiple linear regression analysis to examine the impact of education on the age at onset and the severity of the clinical scores assessed by the Unified Huntington's Disease Rating Scale (UHDRS) of 891 patients with HD from the multinational observational study “Registry” conducted by the European Huntintgton's Disease Network. The model was adjusted for CAG repeat length and age at the time of assessment. Patients with lengthier education exhibited earlier estimated age at onset but less severe clinical scores (motor = −3.6, P = 0.006; cognitive = 27.0, P < 0.001; behavioral = −3.0, P < 0.001; and functional capacity = 1.1 points, P < 0.001) than those with shorter education, after controlling for age and number of CAG repeats. These differences persisted throughout all quartiles of disease severity. An earlier recognition of symptoms and manifestations among the more educated patients could explain the earlier estimated age at onset in this group. The link between better clinical UHDRS scores and higher education might reflect a beneficial effect of education or its covariates on the course of HD. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23385
Affiliations:
- Allemagne, Espagne, Italie, Pays-Bas, Royaume-Uni
- Angleterre, Bade-Wurtemberg, Communauté de Madrid, District de Tübingen, Hollande-Méridionale, Midlands de l'Ouest
- Birmingham, Leyde, Madrid, Ulm
- Université d'Ulm, Université de Birmingham
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000678
- to stream Istex, to step Curation: 000678
- to stream Istex, to step Checkpoint: 000007
- to stream PubMed, to step Corpus: 001368
- to stream PubMed, to step Curation: 001368
- to stream PubMed, to step Checkpoint: 000F93
- to stream Ncbi, to step Merge: 003056
- to stream Ncbi, to step Curation: 003056
- to stream Ncbi, to step Checkpoint: 003056
- to stream Main, to step Merge: 001328
- to stream Main, to step Curation: 001275
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">What is the impact of education on Huntington's disease?</title><author><name sortKey="L Pez End N, Jose Luis" sort="L Pez End N, Jose Luis" uniqKey="L Pez End N J" first="Jose Luis" last="L Pez-Send N">Jose Luis L Pez-Send N</name></author><author><name sortKey="Royuela, Ana" sort="Royuela, Ana" uniqKey="Royuela A" first="Ana" last="Royuela">Ana Royuela</name></author><author><name sortKey="Trigo, Patricia" sort="Trigo, Patricia" uniqKey="Trigo P" first="Patricia" last="Trigo">Patricia Trigo</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Lange, Herwig" sort="Lange, Herwig" uniqKey="Lange H" first="Herwig" last="Lange">Herwig Lange</name></author><author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name></author><author><name sortKey="Keylock, Jennifer" sort="Keylock, Jennifer" uniqKey="Keylock J" first="Jennifer" last="Keylock">Jennifer Keylock</name></author><author><name sortKey="Rickards, Hugh" sort="Rickards, Hugh" uniqKey="Rickards H" first="Hugh" last="Rickards">Hugh Rickards</name></author><author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name></author><author><name sortKey="Squitieri, Ferdinando" sort="Squitieri, Ferdinando" uniqKey="Squitieri F" first="Ferdinando" last="Squitieri">Ferdinando Squitieri</name></author><author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name></author><author><name sortKey="Witjes Ne, Marie Oelle" sort="Witjes Ne, Marie Oelle" uniqKey="Witjes Ne M" first="Marie-Noelle" last="Witjes-Ane">Marie-Noelle Witjes-Ane</name></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline. K." last="Jurgens">Caroline. K. Jurgens</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund. A. C." last="Roos">Raymund. A. C. Roos</name></author><author><name sortKey="Abraira, Victor" sort="Abraira, Victor" uniqKey="Abraira V" first="Victor" last="Abraira">Victor Abraira</name></author><author><name sortKey="De Yebenes, Justo G" sort="De Yebenes, Justo G" uniqKey="De Yebenes J" first="Justo. G." last="De Yébenes">Justo. G. De Yébenes</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AEECB5031AE532E7B267A3757A316A32BCDE6806</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23385</idno><idno type="url">https://api.istex.fr/document/AEECB5031AE532E7B267A3757A316A32BCDE6806/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000678</idno><idno type="wicri:Area/Istex/Curation">000678</idno><idno type="wicri:Area/Istex/Checkpoint">000007</idno><idno type="wicri:doubleKey">0885-3185:2011:L Pez End N J:what:is:the</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:21432905</idno><idno type="wicri:Area/PubMed/Corpus">001368</idno><idno type="wicri:Area/PubMed/Curation">001368</idno><idno type="wicri:Area/PubMed/Checkpoint">000F93</idno><idno type="wicri:Area/Ncbi/Merge">003056</idno><idno type="wicri:Area/Ncbi/Curation">003056</idno><idno type="wicri:Area/Ncbi/Checkpoint">003056</idno><idno type="wicri:Area/Main/Merge">001328</idno><idno type="wicri:Area/Main/Curation">001275</idno><idno type="wicri:Area/Main/Exploration">001275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">What is the impact of education on Huntington's disease?</title><author><name sortKey="L Pez End N, Jose Luis" sort="L Pez End N, Jose Luis" uniqKey="L Pez End N J" first="Jose Luis" last="L Pez-Send N">Jose Luis L Pez-Send N</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Ramon y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, ISCIII, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Royuela, Ana" sort="Royuela, Ana" uniqKey="Royuela A" first="Ana" last="Royuela">Ana Royuela</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Biostatistics Unit, Hospital Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Trigo, Patricia" sort="Trigo, Patricia" uniqKey="Trigo P" first="Patricia" last="Trigo">Patricia Trigo</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Ramon y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, ISCIII, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Lange, Herwig" sort="Lange, Herwig" uniqKey="Lange H" first="Herwig" last="Lange">Herwig Lange</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Reha Zentrum Dinslaken, Dinslaken</wicri:regionArea><wicri:noRegion>Dinslaken</wicri:noRegion><wicri:noRegion>Dinslaken</wicri:noRegion></affiliation></author><author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Muenster, Muenster</wicri:regionArea><wicri:noRegion>Muenster</wicri:noRegion><wicri:noRegion>Muenster</wicri:noRegion></affiliation></author><author><name sortKey="Keylock, Jennifer" sort="Keylock, Jennifer" uniqKey="Keylock J" first="Jennifer" last="Keylock">Jennifer Keylock</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Rickards, Hugh" sort="Rickards, Hugh" uniqKey="Rickards H" first="Hugh" last="Rickards">Hugh Rickards</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Squitieri, Ferdinando" sort="Squitieri, Ferdinando" uniqKey="Squitieri F" first="Ferdinando" last="Squitieri">Ferdinando Squitieri</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurogenetics and Rare Disease Centre, IRCCS Neuromed, Pozzili</wicri:regionArea><wicri:noRegion>Pozzili</wicri:noRegion></affiliation></author><author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Witjes Ne, Marie Oelle" sort="Witjes Ne, Marie Oelle" uniqKey="Witjes Ne M" first="Marie-Noelle" last="Witjes-Ane">Marie-Noelle Witjes-Ane</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline. K." last="Jurgens">Caroline. K. Jurgens</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund. A. C." last="Roos">Raymund. A. C. Roos</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Abraira, Victor" sort="Abraira, Victor" uniqKey="Abraira V" first="Victor" last="Abraira">Victor Abraira</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinical Biostatistics Unit, Hospital Ramón y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="De Yebenes, Justo G" sort="De Yebenes, Justo G" uniqKey="De Yebenes J" first="Justo. G." last="De Yébenes">Justo. G. De Yébenes</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Ramon y Cajal, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, ISCIII, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07">2011-07</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1489">1489</biblScope><biblScope unit="page" to="1495">1495</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AEECB5031AE532E7B267A3757A316A32BCDE6806</idno><idno type="DOI">10.1002/mds.23385</idno><idno type="ArticleID">MDS23385</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Cognition Disorders (etiology)</term><term>Educational Status</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (genetics)</term><term>Huntington Disease (psychology)</term><term>Huntington's disease</term><term>Male</term><term>Mental Disorders (etiology)</term><term>Middle Aged</term><term>Phenotype</term><term>Regression Analysis</term><term>Severity of Illness Index</term><term>Trinucleotide Repeat Expansion (genetics)</term><term>UHDRS scores</term><term>age at onset</term><term>education</term><term>neuroprotection</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Mental Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term><term>Trinucleotide Repeat Expansion</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Educational Status</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Huntington's disease (HD) is a neurodegenerative disease caused by a cytosine adenosine guanine (CAG) expansion in the huntingtin gene. The length of the triplet repeat is the most important factor in determining age of onset and the severity of the disease, but substantial variability of these parameters is attributed to other factors. To investigate the relationship between the years of education and the age at onset and the severity of the phenotype in patients with HD, we applied multiple linear regression analysis to examine the impact of education on the age at onset and the severity of the clinical scores assessed by the Unified Huntington's Disease Rating Scale (UHDRS) of 891 patients with HD from the multinational observational study “Registry” conducted by the European Huntintgton's Disease Network. The model was adjusted for CAG repeat length and age at the time of assessment. Patients with lengthier education exhibited earlier estimated age at onset but less severe clinical scores (motor = −3.6, P = 0.006; cognitive = 27.0, P < 0.001; behavioral = −3.0, P < 0.001; and functional capacity = 1.1 points, P < 0.001) than those with shorter education, after controlling for age and number of CAG repeats. These differences persisted throughout all quartiles of disease severity. An earlier recognition of symptoms and manifestations among the more educated patients could explain the earlier estimated age at onset in this group. The link between better clinical UHDRS scores and higher education might reflect a beneficial effect of education or its covariates on the course of HD. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Communauté de Madrid</li><li>District de Tübingen</li><li>Hollande-Méridionale</li><li>Midlands de l'Ouest</li></region><settlement><li>Birmingham</li><li>Leyde</li><li>Madrid</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li><li>Université de Birmingham</li></orgName></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="L Pez End N, Jose Luis" sort="L Pez End N, Jose Luis" uniqKey="L Pez End N J" first="Jose Luis" last="L Pez-Send N">Jose Luis L Pez-Send N</name></region><name sortKey="Abraira, Victor" sort="Abraira, Victor" uniqKey="Abraira V" first="Victor" last="Abraira">Victor Abraira</name><name sortKey="Abraira, Victor" sort="Abraira, Victor" uniqKey="Abraira V" first="Victor" last="Abraira">Victor Abraira</name><name sortKey="De Yebenes, Justo G" sort="De Yebenes, Justo G" uniqKey="De Yebenes J" first="Justo. G." last="De Yébenes">Justo. G. De Yébenes</name><name sortKey="De Yebenes, Justo G" sort="De Yebenes, Justo G" uniqKey="De Yebenes J" first="Justo. G." last="De Yébenes">Justo. G. De Yébenes</name><name sortKey="L Pez End N, Jose Luis" sort="L Pez End N, Jose Luis" uniqKey="L Pez End N J" first="Jose Luis" last="L Pez-Send N">Jose Luis L Pez-Send N</name><name sortKey="Royuela, Ana" sort="Royuela, Ana" uniqKey="Royuela A" first="Ana" last="Royuela">Ana Royuela</name><name sortKey="Royuela, Ana" sort="Royuela, Ana" uniqKey="Royuela A" first="Ana" last="Royuela">Ana Royuela</name><name sortKey="Trigo, Patricia" sort="Trigo, Patricia" uniqKey="Trigo P" first="Patricia" last="Trigo">Patricia Trigo</name><name sortKey="Trigo, Patricia" sort="Trigo, Patricia" uniqKey="Trigo P" first="Patricia" last="Trigo">Patricia Trigo</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></region><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name><name sortKey="Lange, Herwig" sort="Lange, Herwig" uniqKey="Lange H" first="Herwig" last="Lange">Herwig Lange</name><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Keylock, Jennifer" sort="Keylock, Jennifer" uniqKey="Keylock J" first="Jennifer" last="Keylock">Jennifer Keylock</name></region><name sortKey="Rickards, Hugh" sort="Rickards, Hugh" uniqKey="Rickards H" first="Hugh" last="Rickards">Hugh Rickards</name></country><country name="Italie"><noRegion><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name></noRegion><name sortKey="Squitieri, Ferdinando" sort="Squitieri, Ferdinando" uniqKey="Squitieri F" first="Ferdinando" last="Squitieri">Ferdinando Squitieri</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Witjes Ne, Marie Oelle" sort="Witjes Ne, Marie Oelle" uniqKey="Witjes Ne M" first="Marie-Noelle" last="Witjes-Ane">Marie-Noelle Witjes-Ane</name></region><name sortKey="Jurgens, Caroline K" sort="Jurgens, Caroline K" uniqKey="Jurgens C" first="Caroline. K." last="Jurgens">Caroline. K. Jurgens</name><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund. A. C." last="Roos">Raymund. A. C. Roos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001275 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001275 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:AEECB5031AE532E7B267A3757A316A32BCDE6806
|texte= What is the impact of education on Huntington's disease?
}}
| This area was generated with Dilib version V0.6.23. |  |